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3R8A

X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity

Summary for 3R8A
Entry DOI10.2210/pdb3r8a/pdb
Related2Q8S 3IA6
DescriptorPeroxisome proliferator-activated receptor gamma, 2-ethyl-5,7-dimethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3H-imidazo[4,5-b]pyridine (3 entities in total)
Functional Keywordsnuclear hormone activator, angiotensin ii type i receptor antagonist, ligand bound structure, diabetes mellitus, metabolic syndrome, obesity, nuclear protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight65530.15
Authors
Ohren, J.F. (deposition date: 2011-03-23, release date: 2012-03-14, Last modification date: 2023-09-13)
Primary citationCasimiro-Garcia, A.,Filzen, G.F.,Flynn, D.,Bigge, C.F.,Chen, J.,Davis, J.A.,Dudley, D.A.,Edmunds, J.J.,Esmaeil, N.,Geyer, A.,Heemstra, R.J.,Jalaie, M.,Ohren, J.F.,Ostroski, R.,Ellis, T.,Schaum, R.P.,Stoner, C.
Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-gamma.
J.Med.Chem., 54:4219-4233, 2011
Cited by
PubMed: 21557540
DOI: 10.1021/jm200409s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.41 Å)
Structure validation

217705

数据于2024-03-27公开中

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