3R8A

X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Peroxisome proliferator-activated receptor gamma	polymer	282	32329.5	2	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (human)	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
2	A, B	2-ethyl-5,7-dimethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3H-imidazo[4,5-b]pyridine	non-polymer		435.5	2	Chemie (HIG)
3		water	water		18.0	93	Chemie (HOH)

Sequence modifications

A, B: 207 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 196	-	expression tag
Lys 197	-	expression tag
Lys 198	-	expression tag
Gly 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
Gly 206	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64659.1
Non-Polymers*	Number of molecules	2
	Total formula weight	871.0
All*	Total formula weight	65530.1

*Water molecules are not included.