3R8A

X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity

3R8A の概要

• エントリーDOI: 10.2210/pdb3r8a/pdb
• 関連するPDBエントリー: 2Q8S 3IA6
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-ethyl-5,7-dimethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3H-imidazo[4,5-b]pyridine (3 entities in total)
• 機能のキーワード: nuclear hormone activator, angiotensin ii type i receptor antagonist, ligand bound structure, diabetes mellitus, metabolic syndrome, obesity, nuclear protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65530.15

構造登録者

Ohren, J.F. (登録日: 2011-03-23, 公開日: 2012-03-14, 最終更新日: 2023-09-13)

• 主引用文献: Casimiro-Garcia, A.,Filzen, G.F.,Flynn, D.,Bigge, C.F.,Chen, J.,Davis, J.A.,Dudley, D.A.,Edmunds, J.J.,Esmaeil, N.,Geyer, A.,Heemstra, R.J.,Jalaie, M.,Ohren, J.F.,Ostroski, R.,Ellis, T.,Schaum, R.P.,Stoner, C.; Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-gamma.; J.Med.Chem., 54:4219-4233, 2011; PubMed: 21557540; DOI: 10.1021/jm200409s

実験手法

X-RAY DIFFRACTION (2.41 Å)