3R1G
Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody
Summary for 3R1G
Entry DOI | 10.2210/pdb3r1g/pdb |
Descriptor | Beta-secretase 1, FAB of YW412.8.31 antibody heavy chain, FAB of YW412.8.31 antibody light chain, ... (4 entities in total) |
Functional Keywords | aspartal protease, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 3 |
Total formula weight | 91285.18 |
Authors | |
Primary citation | Atwal, J.K.,Chen, Y.,Chiu, C.,Mortensen, D.L.,Meilandt, W.J.,Liu, Y.,Heise, C.E.,Hoyte, K.,Luk, W.,Lu, Y.,Peng, K.,Wu, P.,Rouge, L.,Zhang, Y.,Lazarus, R.A.,Scearce-Levie, K.,Wang, W.,Wu, Y.,Tessier-Lavigne, M.,Watts, R.J. A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-{beta} Production in Vivo. Sci Transl Med, 3:84ra43-84ra43, 2011 Cited by PubMed: 21613622DOI: 10.1126/scitranslmed.3002254 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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