3R1G
Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Beta-secretase 1 | polymer | 402 | 44643.1 | 1 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (human) | Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
| 2 | B (H) | FAB of YW412.8.31 antibody heavy chain | polymer | 222 | 23282.1 | 1 | Homo sapiens | ||
| 3 | C (L) | FAB of YW412.8.31 antibody light chain | polymer | 214 | 23359.9 | 1 | Homo sapiens | ||
| 4 | D, E, F (B, H, L) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
B: 57 - 453 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly 55 | - | EXPRESSION TAG |
| Ser 56 | - | EXPRESSION TAG |
| Gly 454 | - | EXPRESSION TAG |
| Asn 455 | - | EXPRESSION TAG |
| Ser 456 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 91285.2 | |
| All* | Total formula weight | 91285.2 |
