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3R0T

Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-5279

Summary for 3R0T
Entry DOI10.2210/pdb3r0t/pdb
Related3PE1 3PE2
DescriptorCasein kinase II subunit alpha, 3-(cyclopropylamino)-5-{[3-(trifluoromethyl)phenyl]amino}pyrimido[4,5-c]quinoline-8-carboxylic acid, SULFATE ION, ... (6 entities in total)
Functional Keywordskinase, ck2-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight41729.28
Authors
Battistutta, R.,Papinutto, E.,Lolli, G.,Pierre, F.,Haddach, M.,Ryckman, D.M. (deposition date: 2011-03-09, release date: 2011-12-07, Last modification date: 2023-09-13)
Primary citationBattistutta, R.,Cozza, G.,Pierre, F.,Papinutto, E.,Lolli, G.,Sarno, S.,O'Brien, S.E.,Siddiqui-Jain, A.,Haddach, M.,Anderes, K.,Ryckman, D.M.,Meggio, F.,Pinna, L.A.
Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50:8478-8488, 2011
Cited by
PubMed: 21870818
DOI: 10.1021/bi2008382
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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건을2024-03-13부터공개중

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