3QW7

Crystal structure of the protease domain of Botulinum Neurotoxin Serotype A with a peptide inhibitor RRFC

3QW7 の概要

• エントリーDOI: 10.2210/pdb3qw7/pdb
• 関連するPDBエントリー: 3BWI 3C88 3C89 3C8A 3C8B 3DDA 3DDB 3QW5 3QW6 3QW8
• 分子名称: Botulinum neurotoxin type A, inhibitory peptide RRFC, ZINC ION, ... (6 entities in total)
• 機能のキーワード: endopeptidase, syntaxin, bio-warfare agent, membrane, metal-binding, metalloprotease, protease, secreted, transmembrane, snap25, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Clostridium botulinum
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50373.04

構造登録者

Kumaran, D.,Swaminathan, S. (登録日: 2011-02-27, 公開日: 2012-02-08, 最終更新日: 2023-09-13)

• 主引用文献: Kumar, G.,Kumaran, D.,Ahmed, S.A.,Swaminathan, S.; Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling.; Acta Crystallogr.,Sect.D, 68:511-520, 2012; PubMed: 22525749; DOI: 10.1107/S0907444912003551

実験手法

X-RAY DIFFRACTION (1.5 Å)