3BWI
Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with an acetate ion bound at the active site
Summary for 3BWI
Entry DOI | 10.2210/pdb3bwi/pdb |
Descriptor | Botulinum neurotoxin A light chain, ZINC ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | botulinum neurotoxin type a, catalytic domain, endopeptidase, bio-warfare agent, hydrolase, metalloprotease, pharmaceutical, protease, secreted, zinc |
Biological source | Clostridium botulinum |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 |
Total number of polymer chains | 1 |
Total formula weight | 49974.57 |
Authors | Kumaran, D.,Rawat, R.,Swaminathan, S. (deposition date: 2008-01-09, release date: 2008-04-22, Last modification date: 2023-08-30) |
Primary citation | Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S. Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A J.Biol.Chem., 283:18883-18891, 2008 Cited by PubMed: 18434312DOI: 10.1074/jbc.M801240200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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