3DDB

Crystal structure of the catalytic domain of Botulinum neurotoxin serotype a with a substrate analog peptide

Summary for 3DDB

Entry DOI	10.2210/pdb3ddb/pdb
Related	3BWI 3C88 3C89 3C8A 3C8B 3DDA
Descriptor	Botulinum neurotoxin A light chain, Synaptosomal-associated protein 25, ZINC ION, ... (5 entities in total)
Functional Keywords	botulinum neurotoxin type a, botox, catalytic domain, endopeptidase, syntaxin, bio-warfare agent, hydrolase, metal-binding, metalloprotease, protease, secreted, transmembrane, zinc, enzyme-substrate complex, pharmaceutical
Biological source	Clostridium botulinum More
Cellular location	Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
Total number of polymer chains	2
Total formula weight	50436.23
Authors	Kumaran, D.,Swaminathan, S. (deposition date: 2008-06-05, release date: 2008-09-16, Last modification date: 2023-08-30)
Primary citation	Kumaran, D.,Rawat, R.,Ahmed, S.A.,Swaminathan, S. Substrate binding mode and its implication on drug design for botulinum neurotoxin A Plos Pathog., 4:e1000165-e1000165, 2008 Cited by PubMed: 18818739 DOI: 10.1371/journal.ppat.1000165 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation