3QUP

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

Summary for 3QUP

DescriptorTyrosine-protein kinase receptor TYRO3, (5-fluoro-1H-indol-2-yl)[(3R)-1'-[(3R)-piperidin-3-yl]spiro[indole-3,3'-pyrrolidin]-1(2H)-yl]methanone (3 entities in total)
Functional Keywordsprotein kinase inhibitor, receptor tyrosine kinase, spirocycle, kinase domain, phosphotransfer, gas6 ligand, cytoplasmic surface, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMus musculus (mouse)
Cellular locationCell membrane; Single-pass type I membrane protein P55144
Total number of polymer chains1
Total molecular weight37189.96
Authors
Ohren, J.F. (deposition date: 2011-02-24, release date: 2011-12-21, Last modification date: 2012-01-11)
Primary citation
Powell, N.A.,Kohrt, J.T.,Filipski, K.J.,Kaufman, M.,Sheehan, D.,Edmunds, J.E.,Delaney, A.,Wang, Y.,Bourbonais, F.,Lee, D.Y.,Schwende, F.,Sun, F.,McConnell, P.,Catana, C.,Chen, H.,Ohren, J.,Perrin, L.A.
Novel and selective spiroindoline-based inhibitors of sky kinase.
Bioorg.Med.Chem.Lett., 22:190-193, 2012
PubMed: 22119469 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2011.11.036
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.259706.2%15.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution