3QS1
Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum
Summary for 3QS1
Entry DOI | 10.2210/pdb3qs1/pdb |
Related | 3QRV |
Related PRD ID | PRD_000575 |
Descriptor | Plasmepsin-1, (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL (3 entities in total) |
Functional Keywords | aspartic protease, malaria, kni, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum |
Cellular location | Vacuole: P39898 |
Total number of polymer chains | 4 |
Total formula weight | 154830.77 |
Authors | Bhaumik, P.,Gustchina, A.,Wlodawer, A. (deposition date: 2011-02-19, release date: 2011-05-11, Last modification date: 2012-12-12) |
Primary citation | Bhaumik, P.,Horimoto, Y.,Xiao, H.,Miura, T.,Hidaka, K.,Kiso, Y.,Wlodawer, A.,Yada, R.Y.,Gustchina, A. Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum. J.Struct.Biol., 175:73-84, 2011 Cited by PubMed: 21521654DOI: 10.1016/j.jsb.2011.04.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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