3QS1

Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum

Summary for 3QS1

• Entry DOI: 10.2210/pdb3qs1/pdb
• Related: 3QRV
• Related PRD ID: PRD_000575
• Descriptor: Plasmepsin-1, (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, GLYCEROL (3 entities in total)
• Functional Keywords: aspartic protease, malaria, kni, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum
• Cellular location: Vacuole: P39898
• Total number of polymer chains: 4
• Total formula weight: 154830.77

Authors

Bhaumik, P.,Gustchina, A.,Wlodawer, A. (deposition date: 2011-02-19, release date: 2011-05-11, Last modification date: 2012-12-12)

• Primary citation: Bhaumik, P.,Horimoto, Y.,Xiao, H.,Miura, T.,Hidaka, K.,Kiso, Y.,Wlodawer, A.,Yada, R.Y.,Gustchina, A.; Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.; J.Struct.Biol., 175:73-84, 2011; PubMed: 21521654; DOI: 10.1016/j.jsb.2011.04.009

Experimental method

X-RAY DIFFRACTION (3.1 Å)