3QS1

Crystal structure of KNI-10006 complex of Plasmepsin I (PMI) from Plasmodium falciparum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 006 A 330

Chain	Residue
A	ASP32
A	THR218
A	SER219
A	THR222
A	ILE287
A	LEU291
A	GLY34
A	SER35
A	TYR75
A	VAL76
A	SER77
A	TYR189
A	ASP215
A	GLY217

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 006 B 330

Chain	Residue
A	PHE242
B	ASP32
B	GLY34
B	ASN74
B	TYR75
B	VAL76
B	SER77
B	LEU128
B	TYR189
B	ASP215
B	GLY217
B	THR218
B	SER219
B	ILE287
B	ILE300

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 006 C 330

Chain	Residue
C	ASP32
C	GLY34
C	SER35
C	TYR75
C	VAL76
C	SER77
C	ILE130
C	TYR189
C	ASP215
C	GLY217
C	THR218
C	SER219
C	ILE287
C	LEU291
D	PHE242

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 006 D 330

Chain	Residue
C	PHE242
D	ILE30
D	ASP32
D	GLY34
D	SER35
D	TYR75
D	VAL76
D	SER77
D	ILE130
D	TYR189
D	ASP215
D	GLY217
D	THR218
D	SER219
D	ILE287
D	ILE300
D	GOL332

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 331

Chain	Residue
B	TYR189
B	LEU291
B	ASN292

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 331

Chain	Residue
C	PRO110
C	ALA111
C	LEU114
C	GLY115
D	LYS239
D	PHE242

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 331

Chain	Residue
A	LEU291
A	ASN292
A	THR298

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 332

Chain	Residue
A	SER219
A	SER220
A	SER285

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 331

Chain	Residue
D	ASP193
D	LEU194
D	ASP195
D	ARG261
D	SER262
D	ALA263

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL C 332

Chain	Residue
C	PRO243

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 333

Chain	Residue
A	VAL76

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 332

Chain	Residue
D	VAL76
D	VAL289
D	006330

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 333

Chain	Residue
C	TYR189
C	GLN191
C	LEU291
C	ASN292

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL B 332

Chain	Residue
B	ASN297

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FIFDTGSANLWV

Chain	Residue	Details
A	PHE29-VAL40
A	ALA212-ALA223

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1228
Details	Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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