3QPP

Structure of PDE10-inhibitor complex

3QPP の概要

• エントリーDOI: 10.2210/pdb3qpp/pdb
• 関連するPDBエントリー: 2O8H 2OVV 2OVY 3QPN 3QPO
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: phosphodiesterase inhibitors, structure-based drug design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cytoplasm: Q9QYJ6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42494.35

構造登録者

Pandit, J.,Marr, E.S. (登録日: 2011-02-14, 公開日: 2011-06-15, 最終更新日: 2024-02-21)

• 主引用文献: Helal, C.J.,Kang, Z.,Hou, X.,Pandit, J.,Chappie, T.A.,Humphrey, J.M.,Marr, E.S.,Fennell, K.F.,Chenard, L.K.,Fox, C.,Schmidt, C.J.,Williams, R.D.,Chapin, D.S.,Siuciak, J.,Lebel, L.,Menniti, F.,Cianfrogna, J.,Fonseca, K.R.,Nelson, F.R.,O'Connor, R.,Macdougall, M.,McDowell, L.,Liras, S.; Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia.; J.Med.Chem., 54:4536-4547, 2011; PubMed: 21650160; DOI: 10.1021/jm2001508

実験手法

X-RAY DIFFRACTION (1.8 Å)