3QN7
Potent and selective bicyclic peptide inhibitor (UK18) of human urokinase-type plasminogen activator(uPA)
Summary for 3QN7
| Entry DOI | 10.2210/pdb3qn7/pdb |
| Related | 1LMW 2NWN |
| Descriptor | Urokinase-type plasminogen activator, Bicyclic peptide inhibitor, 1,3,5-tris(bromomethyl)benzene, ... (4 entities in total) |
| Functional Keywords | bicyclic peptide inhibitor, chymotrypsin fold, serine protease, urokinase receptor (upar), extracellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted: P00749 |
| Total number of polymer chains | 2 |
| Total formula weight | 30592.25 |
| Authors | Angelini, A.,Cendron, L.,Touati, J.,Winter, G.,Zanotti, G.,Heinis, C. (deposition date: 2011-02-08, release date: 2012-02-15, Last modification date: 2023-11-01) |
| Primary citation | Angelini, A.,Cendron, L.,Chen, S.,Touati, J.,Winter, G.,Zanotti, G.,Heinis, C. Bicyclic peptide inhibitor reveals large contact interface with a protease target Acs Chem.Biol., 7:817-821, 2012 Cited by PubMed: 22304751DOI: 10.1021/cb200478t PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
