3QN7
Potent and selective bicyclic peptide inhibitor (UK18) of human urokinase-type plasminogen activator(uPA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase-type plasminogen activator | polymer | 253 | 28442.4 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | U-plasminogen activator, uPA |
| 2 | B (B) | Bicyclic peptide inhibitor | polymer | 17 | 1793.0 | 1 | UK18 | ||
| 3 | C (B) | 1,3,5-tris(bromomethyl)benzene | non-polymer | 356.9 | 1 | Chemie (ZBR) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 1 - 253 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 121 | Cys 299 | engineered mutation |
| Gln 144 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30235.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 356.9 | |
| All* | Total formula weight | 30592.3 |
