3QGW
Crystal Structure of ITK kinase bound to an inhibitor
Summary for 3QGW
Entry DOI | 10.2210/pdb3qgw/pdb |
Related | 1SM2 1SNU 1SNX |
Descriptor | Tyrosine-protein kinase ITK/TSK, 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide, N-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide, ... (4 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane (By similarity): Q08881 |
Total number of polymer chains | 2 |
Total formula weight | 65712.00 |
Authors | Brown, K.,Cheetham, G.M.T. (deposition date: 2011-01-25, release date: 2011-06-22, Last modification date: 2024-03-20) |
Primary citation | Charrier, J.D.,Miller, A.,Kay, D.P.,Brenchley, G.,Twin, H.C.,Collier, P.N.,Ramaya, S.,Keily, S.B.,Durrant, S.J.,Knegtel, R.M.,Tanner, A.J.,Brown, K.,Curnock, A.P.,Jimenez, J.M. Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors J.Med.Chem., 54:2341-2350, 2011 Cited by PubMed: 21391610DOI: 10.1021/jm101499u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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