3QEO

S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP

Summary for 3QEO

• Entry DOI: 10.2210/pdb3qeo/pdb
• Related: 3QEJ 3QEN
• Descriptor: Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE, L-deoxythymidine, ... (4 entities in total)
• Functional Keywords: alpha/beta, phosphoryl transfer, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P27707
• Total number of polymer chains: 2
• Total formula weight: 66381.86

Authors

Lavie, A.,Hazra, S. (deposition date: 2011-01-20, release date: 2011-03-16, Last modification date: 2023-09-13)

• Primary citation: Hazra, S.,Szewczak, A.,Ort, S.,Konrad, M.,Lavie, A.; Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.; Biochemistry, 50:2870-2880, 2011; PubMed: 21351740; DOI: 10.1021/bi2001032

Experimental method

X-RAY DIFFRACTION (1.897 Å)