3QBV

Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin

Summary for 3QBV

• Entry DOI: 10.2210/pdb3qbv/pdb
• Related: 1KI1
• Descriptor: Cell division control protein 42 homolog, Intersectin-1, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: computationally designed, orthogonal interaction, gtpase, nucleotide exchange, cell membrane, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, prenylation, cell junction, cell projection, endocytosis, phosphoprotein, sh3 domain, synapse, synaptosome, protein binding-signaling protein complex, protein binding/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): P60953; Endomembrane system (By similarity): Q15811
• Total number of polymer chains: 4
• Total formula weight: 121928.46

Authors

Kapp, G.T.,Remenyi, A.,Lim, W.A.,Kortemme, T. (deposition date: 2011-01-14, release date: 2012-02-08, Last modification date: 2023-09-13)

• Primary citation: Kapp, G.T.,Liu, S.,Stein, A.,Wong, D.T.,Remenyi, A.,Yeh, B.J.,Fraser, J.S.,Taunton, J.,Lim, W.A.,Kortemme, T.; Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.; Proc.Natl.Acad.Sci.USA, 109:5277-5282, 2012; PubMed: 22403064; DOI: 10.1073/pnas.1114487109

Experimental method

X-RAY DIFFRACTION (2.65 Å)