3QBT
Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp
Summary for 3QBT
Entry DOI | 10.2210/pdb3qbt/pdb |
Descriptor | Ras-related protein Rab-8A, Inositol polyphosphate 5-phosphatase OCRL-1, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | protein transport, vesicular trafficking, gtpase, lowe syndrome, immunoglobulin fold, rab8a, ocrl1, endocytosis, clathrin, appl1, phosphoinositide, ash, rhogap, protein transport-hydrolase complex, protein transport/hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Endosome: P61006 Cell membrane; Lipid-anchor; Cytoplasmic side (Potential): Q01968 |
Total number of polymer chains | 8 |
Total formula weight | 148644.94 |
Authors | Hou, X.,Hagemann, N.,Schoebel, S.,Blankenfeldt, W.,Goody, R.S.,Erdmann, K.S.,Itzen, A. (deposition date: 2011-01-14, release date: 2011-03-23, Last modification date: 2023-09-13) |
Primary citation | Hou, X.,Hagemann, N.,Schoebel, S.,Blankenfeldt, W.,Goody, R.S.,Erdmann, K.S.,Itzen, A. A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. Embo J., 30:1659-1670, 2011 Cited by PubMed: 21378754DOI: 10.1038/emboj.2011.60 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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