3QBT

Crystal structure of OCRL1 540-678 in complex with Rab8a:GppNHp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	THR22
A	THR40
A	GNP200
A	HOH219
A	HOH566

---

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GNP A 200

Chain	Residue
A	LYS21
A	THR22
A	CYS23
A	PHE33
A	SER39
A	THR40
A	GLY66
A	ASN121
A	LYS122
A	ASP124
A	VAL125
A	SER151
A	ALA152
A	LYS153
A	HOH180
A	MG201
A	HOH219
A	HOH231
A	HOH566
A	SER17
A	GLY18
A	VAL19
A	GLY20

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 201

Chain	Residue
C	THR22
C	THR40
C	GNP200
C	HOH211
C	HOH252

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GNP C 200

Chain	Residue
C	SER17
C	GLY18
C	VAL19
C	GLY20
C	LYS21
C	THR22
C	CYS23
C	PHE33
C	SER39
C	THR40
C	GLY66
C	ASN121
C	LYS122
C	ASP124
C	VAL125
C	SER151
C	ALA152
C	LYS153
C	HOH195
C	MG201
C	HOH202
C	HOH211
C	HOH252

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 201

Chain	Residue
E	THR22
E	THR40
E	HOH187
E	GNP200
E	HOH309

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GNP E 200

Chain	Residue
E	SER17
E	GLY18
E	VAL19
E	GLY20
E	LYS21
E	THR22
E	CYS23
E	PHE33
E	SER39
E	THR40
E	GLY66
E	ASN121
E	LYS122
E	ASP124
E	VAL125
E	SER151
E	ALA152
E	LYS153
E	HOH182
E	HOH187
E	MG201
E	HOH309
E	HOH593

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 201

Chain	Residue
G	THR22
G	THR40
G	HOH192
G	GNP200
G	HOH302

---

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GNP G 200

Chain	Residue
G	GLY66
G	ASN121
G	LYS122
G	ASP124
G	VAL125
G	SER151
G	ALA152
G	LYS153
G	HOH192
G	HOH193
G	MG201
G	HOH302
G	HOH369
G	SER17
G	GLY18
G	VAL19
G	GLY20
G	LYS21
G	THR22
G	CYS23
G	PHE33
G	SER39
G	THR40

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1

Chain	Residue
A	THR40
B	ARG570
B	LYS665
B	ASP666
B	TYR667

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 2

Chain	Residue
C	ILE41
D	HOH7
D	HOH18
D	ARG570
D	ASP666
D	TYR667

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKtcV

Chain	Residue	Details
A	LEU11-VAL24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:27552051, ECO:0007744|PDB:5SZI

Chain	Residue	Details
A	SER17
G	SER17
G	ASN34
G	ASN121
A	ASN34
A	ASN121
C	SER17
C	ASN34
C	ASN121
E	SER17
E	ASN34
E	ASN121

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9H0U4, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:5SZI

Chain	Residue	Details
A	ASP63
A	ALA152
C	ASP63
C	ALA152
E	ASP63
E	ALA152
G	ASP63
G	ALA152

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by LRRK2 => ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148

Chain	Residue	Details
A	THR72
C	THR72
E	THR72
G	THR72

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