3Q82

Meropenem acylated BlaR1 sensor domain from Staphylococcus aureus

Summary for 3Q82

Entry DOI	10.2210/pdb3q82/pdb
Related	1XA1 3Q7V 3Q7Z 3Q81
Descriptor	Beta-lactamase regulatory protein BlaR1, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	antibiotic-binding, mrsa, antibiotic-binding-antibiotic complex, hydrolase regulator-antibiotic complex, hydrolase regulator/antibiotic
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	60401.93
Authors	Borbulevych, O.Y.,Mobashery, S.,Baker, B.M. (deposition date: 2011-01-05, release date: 2011-07-20, Last modification date: 2013-01-09)
Primary citation	Borbulevych, O.,Kumarasiri, M.,Wilson, B.,Llarrull, L.I.,Lee, M.,Hesek, D.,Shi, Q.,Peng, J.,Baker, B.M.,Mobashery, S. Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus. J.Biol.Chem., 286:31466-31472, 2011 Cited by PubMed: 21775440 DOI: 10.1074/jbc.M111.252189 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation