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3Q2H

Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4

Summary for 3Q2H
Entry DOI10.2210/pdb3q2h/pdb
Related3Q2G
DescriptorA disintegrin and metalloproteinase with thrombospondin motifs 1, ZINC ION, CADMIUM ION, ... (8 entities in total)
Functional Keywordsadamts1 zn-metalloprotease, disintegrin, metalloproteinase, thrombospondin motifs, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (By similarity): Q9UHI8
Total number of polymer chains2
Total formula weight67747.36
Authors
Gerhardt, S.,Hargreaves, D. (deposition date: 2010-12-20, release date: 2011-03-30, Last modification date: 2023-11-01)
Primary citationDe Savi, C.,Pape, A.,Cumming, J.G.,Ting, A.,Smith, P.D.,Burrows, J.N.,Mills, M.,Davies, C.,Lamont, S.,Milne, D.,Cook, C.,Moore, P.,Sawyer, Y.,Gerhardt, S.
The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
Bioorg.Med.Chem.Lett., 21:1376-1381, 2011
Cited by
PubMed: 21300546
DOI: 10.1016/j.bmcl.2011.01.036
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.33 Å)
Structure validation

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