3Q2H
Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | A disintegrin and metalloproteinase with thrombospondin motifs 1 | polymer | 297 | 32578.6 | 2 | UniProt (Q9UHI8) Pfam (PF01421) Pfam (PF17771) In PDB | Homo sapiens (human) | ADAMTS-1 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, B | CADMIUM ION | non-polymer | 112.4 | 4 | Chemie (CD) | |||
| 4 | B, A | NICKEL (II) ION | non-polymer | 58.7 | 14 | Chemie (NI) | |||
| 5 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 6 | B, A | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 7 | B, A | N-[(2S,4S)-1-({4-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl}sulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide | non-polymer | 511.6 | 2 | Chemie (QHF) | |||
| 8 | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 296 (UniProt: Q9UHI8)
| PDB | External Database | Details |
|---|---|---|
| Leu 297 | - | expression tag |
| Val 298 | - | expression tag |
| Pro 299 | - | expression tag |
| Arg 300 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65157.1 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2590.3 | |
| All* | Total formula weight | 67747.4 |
