3PZE

JNK1 in complex with inhibitor

Summary for 3PZE

• Entry DOI: 10.2210/pdb3pze/pdb
• Descriptor: Mitogen-activated protein kinase 8, SULFATE ION, 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide, ... (4 entities in total)
• Functional Keywords: kinase jnk1, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P45983
• Total number of polymer chains: 1
• Total formula weight: 41993.38

Authors

Xue, Y. (deposition date: 2010-12-14, release date: 2011-12-14, Last modification date: 2024-02-21)

• Primary citation: Oza, V.,Ashwell, S.,Almeida, L.,Brassil, P.,Breed, J.,Deng, C.,Gero, T.,Grondine, M.,Horn, C.,Ioannidis, S.,Liu, D.,Lyne, P.,Newcombe, N.,Pass, M.,Read, J.,Ready, S.,Rowsell, S.,Su, M.,Toader, D.,Vasbinder, M.,Yu, D.,Yu, Y.,Xue, Y.,Zabludoff, S.,Janetka, J.; Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas.; J.Med.Chem., 55:5130-5142, 2012; PubMed: 22551018; DOI: 10.1021/jm300025r

Experimental method

X-RAY DIFFRACTION (2 Å)