3PZE

JNK1 in complex with inhibitor

3PZE の概要

• エントリーDOI: 10.2210/pdb3pze/pdb
• 分子名称: Mitogen-activated protein kinase 8, SULFATE ION, 3-(carbamoylamino)-5-phenylthiophene-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: kinase jnk1, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P45983
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41993.38

構造登録者

Xue, Y. (登録日: 2010-12-14, 公開日: 2011-12-14, 最終更新日: 2024-02-21)

• 主引用文献: Oza, V.,Ashwell, S.,Almeida, L.,Brassil, P.,Breed, J.,Deng, C.,Gero, T.,Grondine, M.,Horn, C.,Ioannidis, S.,Liu, D.,Lyne, P.,Newcombe, N.,Pass, M.,Read, J.,Ready, S.,Rowsell, S.,Su, M.,Toader, D.,Vasbinder, M.,Yu, D.,Yu, Y.,Xue, Y.,Zabludoff, S.,Janetka, J.; Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas.; J.Med.Chem., 55:5130-5142, 2012; PubMed: 22551018; DOI: 10.1021/jm300025r

実験手法

X-RAY DIFFRACTION (2 Å)