3PYY

Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site

3PYY の概要

• エントリーDOI: 10.2210/pdb3pyy/pdb
• 分子名称: V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant, SULFATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (7 entities in total)
• 機能のキーワード: tyrosine kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71871.75

構造登録者

Yang, J.,Campobasso, N.,Biju, M.P.,Fisher, K.,Pan, X.Q.,Cottom, J.,Galbraith, S.,Ho, T.,Zhang, H.,Hong, X.,Ward, P.,Hofmann, G.,Siegfried, B. (登録日: 2010-12-13, 公開日: 2011-03-09, 最終更新日: 2024-02-21)

• 主引用文献: Yang, J.,Campobasso, N.,Biju, M.P.,Fisher, K.,Pan, X.Q.,Cottom, J.,Galbraith, S.,Ho, T.,Zhang, H.,Hong, X.,Ward, P.,Hofmann, G.,Siegfried, B.,Zappacosta, F.,Washio, Y.,Cao, P.,Qu, J.,Bertrand, S.,Wang, D.Y.,Head, M.S.,Li, H.,Moores, S.,Lai, Z.,Johanson, K.,Burton, G.,Erickson-Miller, C.,Simpson, G.,Tummino, P.,Copeland, R.A.,Oliff, A.; Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site.; Chem.Biol., 18:177-186, 2011; PubMed: 21338916; DOI: 10.1016/j.chembiol.2010.12.013

実験手法

X-RAY DIFFRACTION (1.85 Å)