3PY8

Crystal structure of a mutant of the large fragment of DNA polymerase I from thermus aquaticus in a closed ternary complex with DNA and ddCTP

3PY8 の概要

• エントリーDOI: 10.2210/pdb3py8/pdb
• 分子名称: DNA polymerase I, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), DNA (5'-D(*AP*A*AP*GP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... (8 entities in total)
• 機能のキーワード: modified klenow fragment, transferase, polymerase, nucleoside binding, nucleic acid binding, dna binding, catalytic activity, dna-directed dna polymerase activity, 5'-3' exonuclease activity, nucleotides, modified nucleotide, artificial nucleotide, nucleotide probes, transferase-dna complex, transferase/dna
• 由来する生物種: Thermus aquaticus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70466.90

構造登録者

Schnur, A.,Marx, A.,Welte, W.,Diederichs, K. (登録日: 2010-12-12, 公開日: 2011-06-15, 最終更新日: 2024-02-21)

• 主引用文献: Obeid, S.,Schnur, A.,Gloeckner, C.,Blatter, N.,Welte, W.,Diederichs, K.,Marx, A.; Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity.; Chembiochem, 12:1574-1580, 2011; PubMed: 21480455; DOI: 10.1002/cbic.201000783

実験手法

X-RAY DIFFRACTION (1.74 Å)