3PUH

Cocaine Esterase, wild-type biologically active dimer

Summary for 3PUH

• Entry DOI: 10.2210/pdb3puh/pdb
• Related: 1ju3 1ju4 3PUI 3i2f 3i2g 3i2h 3i2i 3i2j 3ida
• Descriptor: Cocaine esterase, GLYCEROL, SULFATE ION, ... (4 entities in total)
• Functional Keywords: alpha/beta hydrolase, jelly-roll beta-barrel, cleavage of cocaine, hydrolase
• Biological source: Rhodococcus sp.
• Cellular location: Cytoplasm : Q9L9D7
• Total number of polymer chains: 2
• Total formula weight: 128080.72

Authors

Nance, M.R.,Tesmer, J.J.G. (deposition date: 2010-12-04, release date: 2011-09-21, Last modification date: 2024-02-21)

• Primary citation: Narasimhan, D.,Collins, G.T.,Nance, M.R.,Nichols, J.,Edwald, E.,Chan, J.,Ko, M.C.,Woods, J.H.,Tesmer, J.J.,Sunahara, R.K.; Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.; Mol.Pharmacol., 80:1056-1065, 2011; PubMed: 21890748; DOI: 10.1124/mol.111.074997

Experimental method

X-RAY DIFFRACTION (2.3 Å)