3PUF

Crystal structure of human RNase H2 complex

Summary for 3PUF

• Entry DOI: 10.2210/pdb3puf/pdb
• Descriptor: Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C, ... (4 entities in total)
• Functional Keywords: rnase h fold, triple barrel fold, hydrolase, rnase h
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Probable): O75792 Q5TBB1 Q8TDP1
• Total number of polymer chains: 18
• Total formula weight: 465896.12

Authors

Figiel, M.,Chon, H.,Cerritelli, S.M.,Cybulska, M.,Crouch, R.J.,Nowotny, M. (deposition date: 2010-12-04, release date: 2010-12-22, Last modification date: 2023-11-01)

• Primary citation: Figiel, M.,Chon, H.,Cerritelli, S.M.,Cybulska, M.,Crouch, R.J.,Nowotny, M.; The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.; J.Biol.Chem., 286:10540-10550, 2011; PubMed: 21177858; DOI: 10.1074/jbc.M110.181974

Experimental method

X-RAY DIFFRACTION (3.1 Å)