3PTA

Crystal structure of human DNMT1(646-1600) in complex with DNA

Summary for 3PTA

• Entry DOI: 10.2210/pdb3pta/pdb
• Related: 3PT6 3PT9
• Descriptor: DNA (cytosine-5)-methyltransferase 1, DNA (5'-D(*TP*CP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*CP*CP*GP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*CP*GP*GP*AP*GP*GP*CP*TP*CP*AP*CP*GP*GP*GP*A)-3'), ... (5 entities in total)
• Functional Keywords: dnmt1, maintenance dna methylation, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P26358
• Total number of polymer chains: 3
• Total formula weight: 120360.88

Authors

Song, J.,Patel, D.J. (deposition date: 2010-12-02, release date: 2010-12-29, Last modification date: 2024-02-21)

• Primary citation: Song, J.,Rechkoblit, O.,Bestor, T.H.,Patel, D.J.; Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.; Science, 331:1036-1040, 2011; PubMed: 21163962; DOI: 10.1126/science.1195380

Experimental method

X-RAY DIFFRACTION (3.6 Å)