3POZ

EGFR Kinase domain complexed with tak-285

3POZ の概要

• エントリーDOI: 10.2210/pdb3poz/pdb
• 関連するPDBエントリー: 3PP0
• 分子名称: Epidermal growth factor receptor, SULFATE ION, N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide, ... (4 entities in total)
• 機能のキーワード: kinase domain, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38140.28

構造登録者

Aertgeerts, K.,Skene, R.,Sogabe, S. (登録日: 2010-11-23, 公開日: 2011-03-30, 最終更新日: 2023-09-06)

• 主引用文献: Aertgeerts, K.,Skene, R.,Yano, J.,Sang, B.C.,Zou, H.,Snell, G.,Jennings, A.,Iwamoto, K.,Habuka, N.,Hirokawa, A.,Ishikawa, T.,Tanaka, T.,Miki, H.,Ohta, Y.,Sogabe, S.; Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein.; J.Biol.Chem., 286:18756-18765, 2011; PubMed: 21454582; DOI: 10.1074/jbc.M110.206193

実験手法

X-RAY DIFFRACTION (1.5 Å)