3PJQ
Trypanosoma cruzi trans-sialidase-like inactive isoform (including the natural mutation Tyr342His) in complex with lactose
Summary for 3PJQ
Entry DOI | 10.2210/pdb3pjq/pdb |
Related | 1MS0 1S0I 1S0J |
Related PRD ID | PRD_900008 |
Descriptor | Trans-sialidase, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total) |
Functional Keywords | beta-propeller, lectin / similar to actve trans-sialidases, lactose, sugar binding protein |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 71706.53 |
Authors | Oppezzo, P.,Baraibar, M.,Obal, G.,Pritsch, O.,Alzari, P.M.,Buschiazzo, A. (deposition date: 2010-11-10, release date: 2011-06-08, Last modification date: 2020-07-29) |
Primary citation | Oppezzo, P.,Obal, G.,Baraibar, M.A.,Pritsch, O.,Alzari, P.M.,Buschiazzo, A. Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity. Biochim.Biophys.Acta, 1814:1154-1161, 2011 Cited by PubMed: 21570497DOI: 10.1016/j.bbapap.2011.04.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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