3PJQ

Trypanosoma cruzi trans-sialidase-like inactive isoform (including the natural mutation Tyr342His) in complex with lactose

Summary for 3PJQ

Entry DOI	10.2210/pdb3pjq/pdb
Related	1MS0 1S0I 1S0J
Related PRD ID	PRD_900008
Descriptor	Trans-sialidase, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	beta-propeller, lectin / similar to actve trans-sialidases, lactose, sugar binding protein
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	71706.53
Authors	Oppezzo, P.,Baraibar, M.,Obal, G.,Pritsch, O.,Alzari, P.M.,Buschiazzo, A. (deposition date: 2010-11-10, release date: 2011-06-08, Last modification date: 2020-07-29)
Primary citation	Oppezzo, P.,Obal, G.,Baraibar, M.A.,Pritsch, O.,Alzari, P.M.,Buschiazzo, A. Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity. Biochim.Biophys.Acta, 1814:1154-1161, 2011 Cited by PubMed: 21570497 DOI: 10.1016/j.bbapap.2011.04.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation