3PFP

Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor

3PFP の概要

• エントリーDOI: 10.2210/pdb3pfp/pdb
• 関連するPDBエントリー: 2B7O 3KGF 3NUD 3NUE 3NV8
• 分子名称: Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG, MANGANESE (II) ION, (2S)-2,7-bis(phosphonooxy)heptanoic acid, ... (7 entities in total)
• 機能のキーワード: shikimate pathway, mycobacterium tuberculosis, dah7p synthase, aromatic biosynthesis, tim barrel, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103186.75

構造登録者

Reichau, S.,Jiao, W.,Walker, S.R.,Hutton, R.D.,Parker, E.J.,Baker, E.N. (登録日: 2010-10-28, 公開日: 2011-03-16, 最終更新日: 2023-11-01)

• 主引用文献: Reichau, S.,Jiao, W.,Walker, S.R.,Hutton, R.D.,Baker, E.N.,Parker, E.J.; Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design; J.Biol.Chem., 286:16197-16207, 2011; PubMed: 21454647; DOI: 10.1074/jbc.M110.211649

実験手法

X-RAY DIFFRACTION (2.35 Å)