3PFP
Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 700 |
| Chain | Residue |
| A | CYS87 |
| A | HIS369 |
| A | GLU411 |
| A | ASP441 |
| A | 035463 |
| A | 036716 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 035 A 463 |
| Chain | Residue |
| A | PRO134 |
| A | ARG135 |
| A | SER136 |
| A | GLY282 |
| A | GLU283 |
| A | ARG284 |
| A | LYS306 |
| A | ARG337 |
| A | HIS369 |
| A | LYS380 |
| A | GLU411 |
| A | CYS440 |
| A | ASP441 |
| A | HOH469 |
| A | HOH473 |
| A | HOH491 |
| A | HOH503 |
| A | HOH556 |
| A | HOH681 |
| A | MN700 |
| A | CYS87 |
| A | ARG126 |
| A | LYS133 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 036 A 716 |
| Chain | Residue |
| A | CYS87 |
| A | ARG126 |
| A | LYS133 |
| A | ARG135 |
| A | SER136 |
| A | GLY282 |
| A | GLU283 |
| A | ARG284 |
| A | LYS306 |
| A | ARG337 |
| A | HIS369 |
| A | LYS380 |
| A | GLU411 |
| A | ASP441 |
| A | HOH469 |
| A | HOH473 |
| A | HOH491 |
| A | HOH503 |
| A | HOH556 |
| A | HOH681 |
| A | MN700 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 701 |
| Chain | Residue |
| B | CYS87 |
| B | HIS369 |
| B | GLU411 |
| B | ASP441 |
| B | 036463 |
| B | 035771 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 036 B 463 |
| Chain | Residue |
| B | CYS87 |
| B | ARG126 |
| B | LYS133 |
| B | PRO134 |
| B | ARG135 |
| B | SER136 |
| B | GLY282 |
| B | GLU283 |
| B | ARG284 |
| B | LYS306 |
| B | ARG337 |
| B | HIS369 |
| B | LYS380 |
| B | GLU411 |
| B | ASP441 |
| B | HOH488 |
| B | HOH592 |
| B | HOH597 |
| B | HOH606 |
| B | HOH634 |
| B | HOH670 |
| B | MN701 |
| B | HOH749 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 464 |
| Chain | Residue |
| B | ARG435 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 465 |
| Chain | Residue |
| B | ARG23 |
| B | LEU26 |
| B | GLU53 |
| B | ARG256 |
| B | HOH489 |
| B | HOH647 |
| B | HOH663 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 035 B 771 |
| Chain | Residue |
| B | LYS380 |
| B | GLU411 |
| B | ASP441 |
| B | HOH488 |
| B | HOH592 |
| B | HOH597 |
| B | HOH606 |
| B | HOH634 |
| B | HOH670 |
| B | MN701 |
| B | HOH749 |
| B | CYS87 |
| B | ARG126 |
| B | LYS133 |
| B | PRO134 |
| B | ARG135 |
| B | SER136 |
| B | GLY282 |
| B | GLU283 |
| B | ARG284 |
| B | LYS306 |
| B | ARG337 |
| B | HIS369 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16288916, ECO:0007744|PDB:2B7O |
| Chain | Residue | Details |
| A | CYS87 | |
| B | ARG126 | |
| B | GLU283 | |
| B | LYS306 | |
| B | ARG337 | |
| B | HIS369 | |
| B | GLU411 | |
| B | ASP441 | |
| A | ARG126 | |
| A | GLU283 | |
| A | LYS306 | |
| A | ARG337 | |
| A | HIS369 | |
| A | GLU411 | |
| A | ASP441 | |
| B | CYS87 |
