3PFH

X-Ray crystal structure the N,N-dimethyltransferase TylM1 from Streptomyces fradiae in complex with SAH and dTDP-Quip3N

Summary for 3PFH

• Entry DOI: 10.2210/pdb3pfh/pdb
• Related: 3PFG
• Descriptor: N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate, ... (5 entities in total)
• Functional Keywords: n, n-dimethyltransferase, sam binding, dtdp-linked sugar binding, transferase
• Biological source: Streptomyces fradiae
• Total number of polymer chains: 2
• Total formula weight: 59001.35

Authors

Carney, A.E.,Holden, H.M. (deposition date: 2010-10-28, release date: 2010-12-15, Last modification date: 2023-09-06)

• Primary citation: Carney, A.E.,Holden, H.M.; Molecular Architecture of TylM1 from Streptomyces fradiae: An N,N-Dimethyltransferase Involved in the Production of dTDP-d-mycaminose .; Biochemistry, 50:780-787, 2011; PubMed: 21142177; DOI: 10.1021/bi101733y

Experimental method

X-RAY DIFFRACTION (1.792 Å)