3PFH
X-Ray crystal structure the N,N-dimethyltransferase TylM1 from Streptomyces fradiae in complex with SAH and dTDP-Quip3N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, D) | N-methyltransferase | polymer | 263 | 28537.9 | 2 | UniProt (P95748) | Streptomyces fradiae | |
| 2 | C, F (A, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 3 | D, G (A, D) | [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate | non-polymer | 547.3 | 2 | Chemie (T3Q) PubChem (10166003) PubChem (25150860) PubChem (46173864) PubChem (25150859) PubChem (443510) PubChem (162820759) PubChem (59997783) PubChem (89290028) | |||
| 4 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | H, I (A, D) | water | water | 18.0 | 478 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 255 (UniProt: P95748)
| PDB | External Database | Details |
|---|---|---|
| Leu 256 | - | expression tag |
| Glu 257 | - | expression tag |
| His 258 | - | expression tag |
| His 259 | - | expression tag |
| His 260 | - | expression tag |
| His 261 | - | expression tag |
| His 262 | - | expression tag |
| His 263 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57075.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1925.6 | |
| All* | Total formula weight | 59001.3 |
