3PDS

Irreversible Agonist-Beta2 Adrenoceptor Complex

Summary for 3PDS

• Entry DOI: 10.2210/pdb3pds/pdb
• Related: 2RH1
• Descriptor: Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ... (4 entities in total)
• Functional Keywords: gpcr, signaling, beta adrenergic agonist, fusion protein, membrane protein-hydrolase complex, membrane protein/hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : P07550
• Total number of polymer chains: 1
• Total formula weight: 53860.85

Authors

Rosenbaum, D.M.,Zhang, C.,Lyons, J.A.,Holl, R.,Aragao, D.,Arlow, D.H.,Rasmussen, S.G.F.,Choi, H.-J.,DeVree, B.T.,Sunahara, R.K.,Chae, P.S.,Gellman, S.H.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Caffrey, M.,Gmeiner, P.,Kobilka, B.K. (deposition date: 2010-10-24, release date: 2011-01-12, Last modification date: 2023-09-20)

• Primary citation: Rosenbaum, D.M.,Zhang, C.,Lyons, J.A.,Holl, R.,Aragao, D.,Arlow, D.H.,Rasmussen, S.G.F.,Choi, H.J.,Devree, B.T.,Sunahara, R.K.,Chae, P.S.,Gellman, S.H.,Dror, R.O.,Shaw, D.E.,Weis, W.I.,Caffrey, M.,Gmeiner, P.,Kobilka, B.K.; Structure and function of an irreversible agonist-beta(2) adrenoceptor complex; Nature, 469:236-240, 2011; PubMed: 21228876; DOI: 10.1038/nature09665

Experimental method

X-RAY DIFFRACTION (3.5 Å)