3PDQ
Crystal structure of JMJD2A complexed with bipyridyl inhibitor
Summary for 3PDQ
Entry DOI | 10.2210/pdb3pdq/pdb |
Related | 2OQ7 2OX0 2VD7 2WWJ 3NJY |
Descriptor | Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | jmjc domain, oxidoreductase, chromatin regulator, dioxygenase, transcription, iron, 2-oxoglutarate, alpha-ketoglutarate, demethylation, nucleus, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O75164 |
Total number of polymer chains | 2 |
Total formula weight | 89696.57 |
Authors | King, O.N.F.,Chang, K.-H.,Rose, N.R.,Clifton, I.J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2010-10-23, release date: 2011-03-30, Last modification date: 2023-11-01) |
Primary citation | Chang, K.-H.,King, O.N.F.,Tumber, A.,Woon, E.C.,Heightman, T.D.,McDonough, M.A.,Schofield, C.J.,Rose, N.R. Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds Chemmedchem, 6:759-764, 2011 Cited by PubMed: 21412984DOI: 10.1002/cmdc.201100026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.989 Å) |
Structure validation
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