3PDQ
Crystal structure of JMJD2A complexed with bipyridyl inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Lysine-specific demethylase 4A | polymer | 381 | 44326.3 | 2 | UniProt (O75164) Pfam (PF02375) Pfam (PF02373) In PDB | Homo sapiens (human) | JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A |
2 | A, B | NICKEL (II) ION | non-polymer | 58.7 | 2 | Chemie (NI) | |||
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A, B | 4'-[(2-aminoethyl)carbamoyl]-2,2'-bipyridine-4-carboxylic acid | non-polymer | 286.3 | 2 | Chemie (KC6) | |||
5 | A, B | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
6 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
7 | water | water | 18.0 | 552 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 359 (UniProt: O75164)
PDB | External Database | Details |
---|---|---|
Met -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Ser -14 | - | expression tag |
Ser -13 | - | expression tag |
Gly -12 | - | expression tag |
Val -11 | - | expression tag |
Asp -10 | - | expression tag |
Leu -9 | - | expression tag |
Gly -8 | - | expression tag |
Thr -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 88652.5 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1044.0 | |
All* | Total formula weight | 89696.6 |