3P99

Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol

3P99 の概要

• エントリーDOI: 10.2210/pdb3p99/pdb
• 関連するPDBエントリー: 3g1q 3gw9
• 分子名称: Sterol 14-alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,9beta,10alpha,13alpha)-30-cyclopropylidenelanost-7-en-3-ol, ... (4 entities in total)
• 機能のキーワード: cytochrome p450 fold/sterol 14-alpha demethylase, cyp51, oxidoreductase, monooxygenase, hemoprotein, sterol biosynthesis, cytochrome p450 reductase (cpr), endoplasmic reticulum, membrane
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 209026.65

構造登録者

Lepesheva, G.I.,Hargrove, T.Y.,Waterman, M.R.,Wawrzak, Z. (登録日: 2010-10-16, 公開日: 2011-11-30, 最終更新日: 2023-09-06)

• 主引用文献: Hargrove, T.Y.,Wawrzak, Z.,Liu, J.,Waterman, M.R.,Nes, W.D.,Lepesheva, G.I.; Structural complex of sterol 14alpha-demethylase (CYP51) with 14alpha-methylenecyclopropyl-delta7-24, 25-dihydrolanosterol; J.Lipid Res., 53:311-320, 2012; PubMed: 22135275; DOI: 10.1194/jlr.M021865

実験手法

X-RAY DIFFRACTION (3 Å)