3P99
Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Sterol 14-alpha-demethylase | polymer | 453 | 51173.4 | 4 | UniProt (Q385E8) Pfam (PF00067) | Trypanosoma brucei | |
| 2 | E, G, I, K (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, H, J, L (A, B, C, D) | (3alpha,9beta,10alpha,13alpha)-30-cyclopropylidenelanost-7-en-3-ol | non-polymer | 466.8 | 4 | Chemie (LNP) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 29 - 481 (UniProt: Q385E8)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | Pro 29 | engineered mutation |
| Lys 30 | Thr 30 | engineered mutation |
| Leu 31 | Asp 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 204693.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4333.1 | |
| All* | Total formula weight | 209026.7 |
