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3P99

Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005635cellular_componentnuclear envelope
A0005783cellular_componentendoplasmic reticulum
A0008398molecular_functionsterol 14-demethylase activity
A0016125biological_processsterol metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0044091biological_processmembrane biogenesis
A0046872molecular_functionmetal ion binding
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005635cellular_componentnuclear envelope
B0005783cellular_componentendoplasmic reticulum
B0008398molecular_functionsterol 14-demethylase activity
B0016125biological_processsterol metabolic process
B0016491molecular_functionoxidoreductase activity
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0020037molecular_functionheme binding
B0044091biological_processmembrane biogenesis
B0046872molecular_functionmetal ion binding
C0004497molecular_functionmonooxygenase activity
C0005506molecular_functioniron ion binding
C0005635cellular_componentnuclear envelope
C0005783cellular_componentendoplasmic reticulum
C0008398molecular_functionsterol 14-demethylase activity
C0016125biological_processsterol metabolic process
C0016491molecular_functionoxidoreductase activity
C0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C0020037molecular_functionheme binding
C0044091biological_processmembrane biogenesis
C0046872molecular_functionmetal ion binding
D0004497molecular_functionmonooxygenase activity
D0005506molecular_functioniron ion binding
D0005635cellular_componentnuclear envelope
D0005783cellular_componentendoplasmic reticulum
D0008398molecular_functionsterol 14-demethylase activity
D0016125biological_processsterol metabolic process
D0016491molecular_functionoxidoreductase activity
D0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D0020037molecular_functionheme binding
D0044091biological_processmembrane biogenesis
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE HEM A 482
ChainResidue
ATYR103
AARG361
AGLY414
APHE415
AGLY416
AHIS420
ACYS422
AILE423
ATYR116
AARG124
ALEU127
AALA291
AGLY292
ATHR295
ATHR299
ALEU359

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE LNP A 490
ChainResidue
ATYR103
APHE105
APHE110
AALA115
ATYR116
AMET284
AALA287
AALA291
ALEU356
AMET358

site_idAC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE HEM B 482
ChainResidue
BTYR103
BARG124
BLEU127
BALA291
BGLY292
BTHR295
BSER296
BTHR299
BILE350
BLEU359
BARG361
BGLY414
BPHE415
BGLY416
BHIS420
BCYS422
BILE423
BGLY424
BPHE427
BLNP490

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE LNP B 490
ChainResidue
BTYR103
BPHE105
BPHE110
BTYR116
BLEU130
BMET284
BALA287
BALA291
BLEU356
BMET358
BMET460
BHEM482

site_idAC5
Number of Residues17
DetailsBINDING SITE FOR RESIDUE HEM C 482
ChainResidue
CTYR103
CTYR116
CARG124
CLEU127
CGLY292
CTHR295
CPRO355
CLEU359
CARG361
CGLY414
CPHE415
CGLY416
CHIS420
CCYS422
CILE423
CGLY424
CLNP490

site_idAC6
Number of Residues11
DetailsBINDING SITE FOR RESIDUE LNP C 490
ChainResidue
CTYR103
CPHE110
CVAL114
CTYR116
CLEU127
CLEU130
CMET284
CALA287
CALA291
CLEU356
CHEM482

site_idAC7
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM D 482
ChainResidue
DGLY416
DHIS420
DLYS421
DCYS422
DGLY424
DLNP490
DTYR103
DARG124
DLEU127
DLEU134
DALA291
DGLY292
DTHR295
DPRO355
DLEU356
DLEU359
DARG361
DGLY414
DPHE415

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE LNP D 490
ChainResidue
DTYR103
DPHE110
DMET284
DALA287
DALA291
DLEU356
DMET358
DHEM482

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGaGVHKCIG
ChainResidueDetails
APHE415-GLY424

222624

PDB entries from 2024-07-17

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