3P88
FXR bound to isoquinolinecarboxylic acid
Summary for 3P88
Entry DOI | 10.2210/pdb3p88/pdb |
Related | 3P89 |
Descriptor | Farnesoid X receptor, Nuclear receptor coactivator 1, 7-(4-{[3-(2,6-dimethylphenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)isoquinoline-3-carboxylic acid, ... (5 entities in total) |
Functional Keywords | nuclear recptor fxr, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : B6ZGS9 A8K1V4 |
Total number of polymer chains | 2 |
Total formula weight | 28875.96 |
Authors | Madauss, K.P.,Williams, S.P.,Deaton, D.N. (deposition date: 2010-10-13, release date: 2011-08-31, Last modification date: 2024-02-21) |
Primary citation | Bass, J.Y.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Mills, W.Y.,Navas, F.,Parks, D.J.,Smalley, T.L.,Spearing, P.K.,Todd, D.,Williams, S.P.,Wisely, G.B. Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene. Bioorg.Med.Chem.Lett., 21:1206-1213, 2011 Cited by PubMed: 21256005DOI: 10.1016/j.bmcl.2010.12.089 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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