3P88
FXR bound to isoquinolinecarboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Farnesoid X receptor | polymer | 229 | 26870.7 | 1 | UniProt (B6ZGS9) Pfam (PF00104) UniProt (by SIFTS) (Q96RI1) | Homo sapiens (human) | Nuclear receptor subfamily 1, group H, member 4, isoform CRA_a |
| 2 | B (B) | Nuclear receptor coactivator 1 | polymer | 11 | 1416.6 | 1 | UniProt (A8K1V4) UniProt (by SIFTS) (Q15788) | Homo sapiens (Human) | |
| 3 | C (A) | 7-(4-{[3-(2,6-dimethylphenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)isoquinoline-3-carboxylic acid | non-polymer | 492.6 | 1 | Chemie (P88) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 244 - 472 (UniProt: B6ZGS9)
| PDB | External Database | Details |
|---|---|---|
| Glu 285 | Leu 285 | conflict |
| Glu 432 | Cys 432 | engineered mutation |
| Glu 466 | Cys 466 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28287.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 588.6 | |
| All* | Total formula weight | 28876.0 |
