3P5Z
Crystal structure of the mutant T159S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Summary for 3P5Z
| Entry DOI | 10.2210/pdb3p5z/pdb |
| Related | 3LTP 3P5Y 3P60 3P61 |
| Descriptor | Orotidine 5'-monophosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | tim barrel, orotidine 5'-monophosphate decarboxylase, inhibitor bmp, lyase |
| Biological source | Methanobacterium thermoautotrophicum |
| Total number of polymer chains | 2 |
| Total formula weight | 51002.37 |
| Authors | Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-10-11, release date: 2011-09-21, Last modification date: 2023-09-06) |
| Primary citation | Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51:8665-8678, 2012 Cited by PubMed: 23030629DOI: 10.1021/bi301188k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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