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3P5Y

Crystal structure of the mutant T159A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Summary for 3P5Y
Entry DOI10.2210/pdb3p5y/pdb
Related3LTP 3P5Z 3P60 3P61
DescriptorOrotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total)
Functional Keywordstim barrel, orotidine 5'-monophosphate decarboxylase, inhibitor bmp, lyase
Biological sourceMethanothermobacter thermautotrophicus
Total number of polymer chains2
Total formula weight50481.80
Authors
Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-10-11, release date: 2011-09-21, Last modification date: 2023-09-06)
Primary citationDesai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A.
Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.
Biochemistry, 51:8665-8678, 2012
Cited by
PubMed: 23030629
DOI: 10.1021/bi301188k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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