3P56
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Summary for 3P56
Entry DOI | 10.2210/pdb3p56/pdb |
Related | 3KIO 3P5J |
Descriptor | Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C (3 entities in total) |
Functional Keywords | rnase h fold, triple beta-barrel, nuclease that cleaves rna/dna hybrids, proliferating cell nuclear antigen (pcna) and rna/dna hybrids, nucleus, hydrolase-replication complex, hydrolase/replication |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): O75792 Q5TBB1 Q8TDP1 |
Total number of polymer chains | 6 |
Total formula weight | 155811.30 |
Authors | Bubeck, D.,Graham, S.C.,Jones, E.Y. (deposition date: 2010-10-08, release date: 2010-11-17, Last modification date: 2023-09-06) |
Primary citation | Reijns, M.A.,Bubeck, D.,Gibson, L.C.,Graham, S.C.,Baillie, G.S.,Jones, E.Y.,Jackson, A.P. The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease. J.Biol.Chem., 286:10530-10539, 2011 Cited by PubMed: 21177854DOI: 10.1074/jbc.M110.177394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.06 Å) |
Structure validation
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