3P56
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Ribonuclease H2 subunit A | polymer | 299 | 33343.8 | 2 | UniProt (O75792) Pfam (PF01351) In PDB | Homo sapiens (human) | RNase H2 subunit A, Aicardi-Goutieres syndrome 4 protein, AGS4, RNase H(35), Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A |
2 | B, E | Ribonuclease H2 subunit B | polymer | 237 | 26699.7 | 2 | UniProt (Q5TBB1) Pfam (PF17745) Pfam (PF09468) In PDB | Homo sapiens (human) | RNase H2 subunit B, Aicardi-Goutieres syndrome 2 protein, AGS2, Deleted in lymphocytic leukemia 8, Ribonuclease HI subunit B |
3 | C, F | Ribonuclease H2 subunit C | polymer | 164 | 17862.1 | 2 | UniProt (Q8TDP1) Pfam (PF08615) In PDB | Homo sapiens (human) | RNase H2 subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, Ribonuclease HI subunit C |
Sequence modifications
A, D: 1 - 299 (UniProt: O75792)
B, E: 2 - 226 (UniProt: Q5TBB1)
PDB | External Database | Details |
---|---|---|
Ala 34 | Asp 34 | engineered mutation |
Ala 169 | Asp 169 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -10 | - | expression tag |
Pro -9 | - | expression tag |
Leu -8 | - | expression tag |
Gly -7 | - | expression tag |
Ser -6 | - | expression tag |
Pro -5 | - | expression tag |
Glu -4 | - | expression tag |
Phe -3 | - | expression tag |
Pro -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Leu 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 155811.3 | |
All* | Total formula weight | 155811.3 |