3P56
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006260 | biological_process | DNA replication |
| A | 0006298 | biological_process | mismatch repair |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0016070 | biological_process | RNA metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0032299 | cellular_component | ribonuclease H2 complex |
| A | 0043137 | biological_process | DNA replication, removal of RNA primer |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0032299 | cellular_component | ribonuclease H2 complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0006298 | biological_process | mismatch repair |
| C | 0006401 | biological_process | RNA catabolic process |
| C | 0032299 | cellular_component | ribonuclease H2 complex |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004518 | molecular_function | nuclease activity |
| D | 0004519 | molecular_function | endonuclease activity |
| D | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| D | 0004540 | molecular_function | RNA nuclease activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006260 | biological_process | DNA replication |
| D | 0006298 | biological_process | mismatch repair |
| D | 0006401 | biological_process | RNA catabolic process |
| D | 0016070 | biological_process | RNA metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0032299 | cellular_component | ribonuclease H2 complex |
| D | 0043137 | biological_process | DNA replication, removal of RNA primer |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0032299 | cellular_component | ribonuclease H2 complex |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0006298 | biological_process | mismatch repair |
| F | 0006401 | biological_process | RNA catabolic process |
| F | 0032299 | cellular_component | ribonuclease H2 complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CWY8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
