3P56
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
A | 0004540 | molecular_function | RNA nuclease activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006260 | biological_process | DNA replication |
A | 0006298 | biological_process | mismatch repair |
A | 0006401 | biological_process | RNA catabolic process |
A | 0016070 | biological_process | RNA metabolic process |
A | 0032299 | cellular_component | ribonuclease H2 complex |
A | 0043137 | biological_process | DNA replication, removal of RNA primer |
A | 0046872 | molecular_function | metal ion binding |
B | 0032299 | cellular_component | ribonuclease H2 complex |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0006298 | biological_process | mismatch repair |
C | 0006401 | biological_process | RNA catabolic process |
C | 0032299 | cellular_component | ribonuclease H2 complex |
D | 0003676 | molecular_function | nucleic acid binding |
D | 0003723 | molecular_function | RNA binding |
D | 0004519 | molecular_function | endonuclease activity |
D | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
D | 0004540 | molecular_function | RNA nuclease activity |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006260 | biological_process | DNA replication |
D | 0006298 | biological_process | mismatch repair |
D | 0006401 | biological_process | RNA catabolic process |
D | 0016070 | biological_process | RNA metabolic process |
D | 0032299 | cellular_component | ribonuclease H2 complex |
D | 0043137 | biological_process | DNA replication, removal of RNA primer |
D | 0046872 | molecular_function | metal ion binding |
E | 0032299 | cellular_component | ribonuclease H2 complex |
F | 0005515 | molecular_function | protein binding |
F | 0005634 | cellular_component | nucleus |
F | 0006298 | biological_process | mismatch repair |
F | 0006401 | biological_process | RNA catabolic process |
F | 0032299 | cellular_component | ribonuclease H2 complex |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
C | MET1 | |
F | MET1 | |
A | ASP141 | |
D | ALA34 | |
D | GLU35 | |
D | ASP141 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | SER3 | |
F | SER3 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | THR204 | |
A | THR216 | |
D | THR204 | |
D | THR216 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8 |
Chain | Residue | Details |
A | SER257 | |
D | SER257 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER277 | |
D | SER277 |