3P56

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

Summary for 3P56

Related3P5J 3KIO
DescriptorRibonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C (3 entities in total)
Functional Keywordsrnase h fold, triple beta-barrel, nuclease that cleaves rna/dna hybrids, proliferating cell nuclear antigen (pcna) and rna/dna hybrids, nucleus, hydrolase-replication complex, hydrolase/replication
Biological sourceHomo sapiens (human)
Cellular locationNucleus (Probable) O75792 Q5TBB1 Q8TDP1
Total number of polymer chains6
Total molecular weight155811.3
Authors
Bubeck, D.,Graham, S.C.,Jones, E.Y. (deposition date: 2010-10-08, release date: 2010-11-17, Last modification date: 2011-07-13)
Primary citation
Reijns, M.A.,Bubeck, D.,Gibson, L.C.,Graham, S.C.,Baillie, G.S.,Jones, E.Y.,Jackson, A.P.
The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease.
J.Biol.Chem., 286:10530-10539, 2011
PubMed: 21177854 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M110.177394
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (4.06 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.41430.8%6.1%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution